Research

A/Prof Sinclair is an active clinical researcher and participant in clinical trials.  Her main areas of research include continuous laryngeal neuromonitoring during thyroid and parathyroid surgeries using the laryngeal adductor reflex, thermal ablation of benign thyroid nodules, and the laryngeal adductor reflex and pathophysiology of the laryngopharynx. A list of her publications follows. A/Prof Sinclair has been selected as the incoming Editor-in-Chief of  VideoEndocrinology, one of three journals sponsored by the American Thyroid Association.

PUBLICATIONS
  1. Alsen M, Sinclair CF, Cooke P, Ziadkhanpour K, Genden E et al. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics 2021: 9(1), 14;https://doi.org/10.3390/toxics9010014
  2. Sinclair CF. Laryngeal Nerve and Airway Protection During Radiofrequency Ablation of Thyroid Nodules. Videoendocrinology, January 2021.
  3. Sinclair CF, Tellez MJ, Diaz A, Ulkatan S. Continuous Neuromonitoring during Radiofrequency Ablation of Benign Thyroid Nodules Provides Objective Evidence of Laryngeal Nerve Safety. American Journal of Surgery. Published online ahead of print December 23rd 2020.
  4. Dhillon VK, Randolph GW, Stack BC, Lindeman B, Bloom G, Sinclair CF, et al. Immediate and partial neural dysfunction after thyroid and parathyroid surgery: Need for recognition, laryngeal exam and early treatment. Head and Neck, November 2020
  5. Van Gerwen M, Alsen M, Little C, Sinclair CF, Genden E. Outcomes of Patients with Hypothyroidism and COVID-19: A Retrospective Cohort Study. Frontiers in Endocrinology. July 2020.
  6. Van Gerwen M, Sinclair C, Rahman M, Genden E, Taioli E. The impact of surgery refusal on thyroid cancer survival: a SEER-based analysis. Endocrine. 2020; Apr 19 [Epub ahead of print]
  7. Van Gerwen M, Alpert N, Sinclair C, Kale M, Genden E, Taioli E. Assessing non-aggressiveness of untreated, local and regional, papillary thyroid cancer. Oral Oncol 2020; Apr 9; 105: 104674
  8. Van Gerwen M, Alsen M, Lee E, Sinclair CF, Genden E, et al. Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid carcinoma. Journal of Endo Invest. July 2020.
  9. Sinclair CF, Tellez MJ, Ulkatan S. Continuous Laryngeal Adductor Reflex Versus Intermittent Nerve Monitoring in Neck Endocrine Surgery. Laryngoscope, May 2020
  10. Walgama, E, Sinclair CF, Chen AY, et al In Response to ‘Routine Preoperative Laryngoscopy for Thyroid Surgery is Not Necessary Without Risk Factors’. Thyroid 2020; 30(5).
  11. Dhillon VK, Sinclair CF, Scharpf J. Nerve monitoring review. Annals Thyroid 2020. Volume 5.
  12. Leigh N, Sinclair CF. Lingual Osseous Choristoma causing odynophagia in a young female. Ear, Nose & Throat, Accepted for publication October 2020
  13. Sinclair CF, Tellez M, Sanchez Roldan, M, Ulkatan S. Laryngeal adductor reflex hyperexcitability may predict permanent vocal fold paralysis. Laryngoscope, December 2019.
  14. Sawka AM, Gagliardi AR, Haymart M, Sinclair CF, et al, A Surgey of Americal Thyroid Association Members Regarding the 2015 Adult Thyroid nodule and Differentiated Thyroid cancer Clinical Practice Guidelines. Thyroid 2019; 30(1)
  15. Sawka A, Gagliardi AR, Haymart M,….SinclairCF, Jonklass J. A Survey of American Thyroid Association Members Regarding the 2015 Adult Thyroid Nodule and Differentiated Thyroid Cancer Clinical Practice Guidelines. Thyroid 2019 Dec.
  16. Pescador AM, Angeles Sanchez Roldan M, Tellez MJ, Sinclair CF, Ulkatan S. Unforseen Clinical outcome for laryngeal adductor reflex loss during intraaxial brainstem surgery. Clin Neurophysiol. 2019 Jul 19;pii:S1388-2457(19)31155-1
  17. Sinclair CF, Tellez MJ, Sanchez Roldan MA, Urken M, Ulkatan S. Intraoperative mapping and monitoring of sensory vagal fibers during vagal schwannoma resection. Laryngoscope 2019 Jun 18. Doi:10.1002/lary.28147
  18. Sandler ML, Sims JR, Sinclair C, Ho R, Yue LE, Tellez MJ, et al. A novel approach to neurologic function sparing surgical management of vagal schwannomas:Continuous intraoperative nerve monitoring of the laryngeal adductor reflex. Head Neck 2019 May 6. Doi:10.1001/hed.25793
  19. Sandler ML, Sims JR, Sinclair C,Sharif KF, Ho R, et al. Vagal schwannomas of the head and neck: A comprehensive review and a novel approach to preserving vocal cord innervations and function. Head Neck 2019 Jul ;41(7):2450-2466.
  20. Sanchez Roldan MA, Tellez M, Ulkatan S, Sinclair CF. Continuous Vagal Neuromonitoring Using the Laryngeal Adductor Reflex: Can Preincision Dyssynchrony Predict Intraoperative Nerve Behavior? Otolaryngol Head Neck Surg, January 2019.
  21. Ulkatan S, Tellez MJ, Sinclair C. Laryngeal adductor reflex and future projections for brainstem monitoring. Reply to “A method for intraoperative recording of the laryngeal adductor reflex during lower brainstem surgery in children”. Clin Neurophysiol 2018 Nov;129(11):2499-2500.
  22. Sinclair CF, Kamani D, Randolph GW. The evolution and progress of standard procedures for intraoperative nerve monitoring. Ann Thyr, 2019
  23. Sinclair CF. A Surgeon’s Guide to Imaging Surveillance for Well-Differentiated Thyroid Carcinoma and Implications for Revision Central Neck Dissection. Videoendocrinology, Dec 2018; DOI: 10.1089/ve.2018.0143
  24. Schneider R, Randolph GW, Dionigi G, Wu CW, Barczynski M, et al. International neural monitoring study group guideline 2018 part I: Staging bilateral thyroid surgery with monitoring loss of signal. Laryngoscope October 2018
  25. Schneider R, Randolph GW, Dionigi G, Wu CW, Barczynski M, et al. International neural monitoring study group guideline 2018 part 2: Optimal recurrent laryngeal nerve management for invasive thyroid cancer-incorporation of surgical, laryngeal, and neural electrophysiologic data Laryngoscope October 2018.
  26. Ulkatan S, Tellez MJ, Sinclair CF. Comprehensive tube-based methodology for evaluating the laryngeal adductor reflex in humans under anesthesia. Clinical Neurophysiology 2018; 129:e188; DOI: 10.1016/j.clinph.2018.04.484
  27. Sinclair CF, Tellez MJ, Ulkatan S. Sensory receptor mapping in humans illuminates the mechanisms of laryngeal adductor reflex control. Laryngoscope 2018;128(11):E365:370
  28. Sinclair CF, Tellez MJ, Blitzer A, Ulkatan S. Unearthing a consistent bilateral R1 component of the laryngeal adductor reflex in awake humans. Laryngoscope 128(11):2581-87.
  29. Sinclair CF, Tellez MJ, Ulkatan S. Non-invasive, tube-based continuous vagal nerve monitoring using the laryngeal adductor reflex: Feasibility study of 134 nerves at risk. Head and Neck 2018l;1-9.
  30. Sinclair CF, Tellez MJ, Tapia OR, Ulkatan S. Contralateral R1 and R2 components of the Laryngeal Adductor Reflex in humans under general anesthesia. Laryngoscope 2017;127:E443-448
  31. Sinclair CF, Tellez MJ, Tapia OR, Ulkatan S. A novel methodology for assessing laryngeal and vagus nerve integrity in patients under general anesthesia. In press. Neurophysiology 2017. DOI: http://dx.doi.org/10.1016/j.clinph.2017.03.002
  32. Kaye R, Sinclair CF, Blitzer A. The Saline Challenge: A Test of Injection Laryngoplasty Outcome. Accepted for publication in Laryngoscope, August 2017
  33. Fundakowski CE, Hales NW, Agarwal N, et al. Surgical Management of the Recurrent Laryngeal Nerve in Thyroidectomy: A Head and Neck Society Consensus Statement. Accepted for publication in Head Neck, 2018.
  34. Stewart C, Sinclair CF, Blitzer, A. Adductor Spasmodic Dysphonia: Controversies in Phenomenology and Diagnostic Criteria. Accepted for publication in Clinical Movement Disorders,  August 2017.
  35. Al-Ayoubi AM, Rehmani SS, Sinclair CF, Lebovics RS, BhoraFY.Reconstruction of Anterior Tracheal Defects Using a Bioengineered Graft in a Porcine Model. Annals of Thoracic Surgery 2017. 103(2):381-389
  36. Sinclair CF, Bumpous JM, Haugen BR, et al. Laryngeal examination in thyroid and parathyroid surgery: An American Head and Neck Society consensus statement: AHNS Consensus Statement. Head Neck. 2016; Jun;38(6):811-9. doi: 10.1002/hed.24409.
  37. Sinclair CF, Peters GE, Carroll WR. An extended toboggan technique for resection of substernal thyroidEar Nose Throat J. 2016;95(4-5):175-7.
  38. Sinclair CF, Blitzer A. In response to Palatal myoclonus: Algorithm for management with botulinium toxin based on clinical disease characteristics. Laryngoscope 2015;125(10):E355
  39. Tang C, Sinclair CF. Voice Restoration after Total Laryngectomy. In: Otolaryngologic Clinics North America See comment in PubMed Commons below2015;48(4):687-702. doi:10.1016/j.otc.2015.04.013.
  40. Sinclair CF, Simonyan K, Brin M, Blitzer A. Negative dystonia of the palate: a new diagnostic consideration in velopharyngeal imcompetence. Laryngoscope 2015 DOI: 10.1002/lary.25165
  41. Sinclair CF, Gurey LE, Blitzer A. Palatal myoclonus – Algorithm for management with botulinum toxin based on clinical disease characteristics. Laryngoscope 2014 May;124(5):1164-9.
  42. Sinclair CF, Sulica L. Idiopathic Ulcerative Laryngitis causing Granuloma of the Membranous Vocal Fold. Laryngoscope 2013 Feb;123(2):458-9.
  43. Sinclair CF, Strome M. Archives of Otolaryngology, Head and Neck Surgery MOC: Patient with a laryngeal mass. Archives Otolaryngol, Head Neck Surg, March 2013.
  44. Sinclair CF, Gurey LE, Brin MF, et al. Surgical management of airway dysfunction in Parkinson’s Disease compared with Parkinson-plus syndromes. Annals of Otology, Rhinology and Laryngology 2013 May;122(5):294-8.
  45. Sinclair CF, Gurey LE, Blitzer A. Oromandibular Dystonia – Long-term Management with Botulinum Toxin. Laryngoscope 2013 Dec;123(12):3078-83.
  46. Sinclair CF, Carroll WR,  Desmond RA,  Rosenthal, EL.  Functional and Survival Outcomes in Patients Undergoing Total Glossectomy Compared with Total Laryngoglossectomy. Otolaryngol Head Neck Surg;2011;14(5)
  47. Sinclair CF,  Rosenthal EL, McColloch NL et al. Primary versus Delayed Tracheoesophageal Puncture for Laryngopharyngectomy with Free Flap Reconstruction. Laryngoscope 2011; 121(7):1436-40.
  48. Sinclair CF, McColloch NL, Carroll WR et al. Patient perceived and Objective Functional Outcomes Following Transoral Robotic Surgery for Early Oropharyngeal Carcinoma. Arch Otol Head Neck Surg 2011;137(11):1112-6.
  49. Sinclair CF, Gleysteen JP, Wax MK et al. Assessment of Donor Site Morbidity for Osteocutaneous Radial Forearm Free Flaps. Microsurgery – online early view version available; DOI 10. 1002/micr
  50. Sinclair CF, Foushee HR, Scarinci I, et al. Patterns of Blunt Use among Rural Young Adult African American Men. American Journal of Preventive Medicine 2012;42(1): 61-4.
  51. Sinclair CF, Foushee HR, Scarinci I, et al. Perceptions of harm to health from cigarettes, blunts and marijuana among young adult African American Men. Accepted for Publication to Journal of Healthcare for the Poor and Underserved, December 2012.
  52. Sinclair CF, Peters GE, Carroll WR, A technique for substernal goiter resection. Accepted for publication to ENT Journal, July 2011.
  53. Sinclair CF, Berkowitz RG. Prior antibiotic therapy for acute sinusitis in children and the development of subperiosteal orbital abscess. International Journal Pediatric Otorhinolaryngology 2007;71(7): 1003-1006.
  54. Sinclair CF, Childs LF, Rickert S, et al. Saline Vocal Fold Augmentation: A useful test of patient tolerability. Submitted for publication in Laryngoscope, May 2012.
  55. Gurey E, Sinclair CF, Blitzer A. A new paradigm for the management of essential vocal tremor with botulinum toxin. Accepted for publication in Laryngoscope, February 2013.
  56. Carroll WR, Foushee HR, Hardy CM, Floyd T, Sinclair CF, Scarinci I. Tobacco Use among Rural African American Young Adult Males. Otolaryngol Head Neck Surg 2011;145(2):259-63.
  57. Woods SBS, Chee JBL, Sinclair CF et al. Helicobacter status does not relate to post anaesthetic nausea. Helicobacter 2005;10(5):443-444.
Submitted Publications (pending peer review)
  1. Hodak S, Kuo J, Patel K, Sinclair CF. Radiofrequency ablation of benign thyroid nodules: The New York Experience. Submitted to Clinical Endocrinology February 2020
  2. Tellez MJ, Sinclair CF, Ulkatan S et al. Redefining the role of the short-latency laryngeal adductor reflex R1 response in airway protection. Submitted to Laryngoscope January 2021.
  Invited Contributions
  1. Sinclair CF, Russell J. Next Steps and Future directions of Radiofrequency. Current Otorhinolaryngology Reports, Ed. Sinclair CF and Russell J. Accepted February 2021
  2. Sinclair CF. A thoughtful approach to intraoperative neuromonitoring outcomes reporting. In: Nerve Monitoring in Head and Neck Surgery, Current Otorhinolaryngology Reports, Ed. Sinclair CF.
  3. Kuo J, Sinclair CF, et al. Comprehensive review of interventional ablation techniques for the management of thyroid nodules. Invited article for
  4. Sinclair CF. Continuous intraoperative neuromonitoring of the recurrent laryngeal nerve by eliciting the laryngeal adductor reflex (LAR-CIONM). J Innovative Surg Sci, submitted February 2021.
  5. Kaye R, Tang C. Sinclair CF. The electrolarynx: Voice Restoration after Total Laryngectomy. Medical Devices. Invited review. Medical Devices: Evidence and Research, June 2017. Volume 10:133-140.
Books and Book Chapters
  1. Sinclair CF, Dhillon V. Intraoperative Cranial Nerve Monitoring in Otolaryngology-Head and Neck Surgery: Chapter 10, Emerging Trends for Vagus/Recurrent Laryngeal Nerve Monitoring. Ed: Dr Joseph Scharpf, Dr Gregory Randolph, Springer International 2021 (pending publication)
  2. Tellez MJ, Sinclair CF, Ulkatan S. Intraoperative monitoring of the vagus and laryngeal nerves with the laryngeal adductor reflex. Neurophysiology in neurosurgery, Springer, January 2020
  3. Sinclair CF, Kamani D, Randolph G, Sacks B, Baskin JH. Ultrasound and Mapping of Neck Lymph Nodes. In: Handbook of Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA, 4th Duick DS, Levine RA, Lupo MA (eds.) Springer International 2017.
  4. Sinclair CF. Randolph GW. Endocrine Surgery. In: Self Assessment in Otolaryngology; J Shah, JP O’Neill (eds). Elsevier 2016.
  5. Sinclair CF, Duke WS, Barbu AM, Randolph GW. Laryngeal Exam Indications and Techniques. In: The Recurrent and Superior Laryngeal Nerves; GW Randolph (ed). Springer, 2016
  6. Miyauchi A, Sinclair CF, Kamani D, et al. Intraoperative Nerve Injury Management: Transection and Segmental Defects. In: The Recurrent and Superior Laryngeal Nerves; GW Randolph (ed). Springer, 2016(*I was an equal contributor to this chapter)
  7. Sinclair CF, Lebovics RS. Infectious and Inflammatory Disorders of the Larynx. In: Diagnosis and Treatment of Voice Disorders, 4th Rubin J, Sataloff R, Korovin G (eds). Plural, 2013
  8. Sinclair CF, Gurey LE, Blitzer A. Neurologic and Neuromuscular Diseases of the Larynx. In: Clinical Laryngology. Fried M, Tan M (eds). Thieme, 2012
  9. Gross ND, Holsinger FC, Magnuson JS, Sinclair CF. Transoral Robotic Surgery. In: Atlas of Head and Neck Surgery. Cohen JI, Clayman GL (eds). Elsevier, 2011.
Upcoming Journal Editions (Editor Role)
  1. Co-Editor, Current Otorhinolaryngology Reports Special Edition: Radiofrequency Ablation in Neck Endocrine Surgery – Release Date Early 2021
  2. Editor, Current Otorhinolaryngology Reports Special Edition: Neuromonitoring in the Head and Neck – Release Date Early 2021
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